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PDB MMDB Reactome pathway
UniProtKB/SwissProt
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Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093359(2-(4-Hydroxymethyl-phenyl)-1H-benzoimidazole-4-car...)

Ki: 1.60nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093384(2-(3-Hydroxy-4-methoxy-phenyl)-1H-benzoimidazole-4...)

Ki: 2nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093372(2-(4-Chloro-phenyl)-1H-benzoimidazole-4-carboxylic...)

Ki: 3nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093379(2-(4-Cyano-phenyl)-1H-benzoimidazole-4-carboxylic ...)

Ki: 4nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093362(2-(3,4-Dimethoxy-phenyl)-1H-benzoimidazole-4-carbo...)

Ki: 5.40nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093361(2-(4-Dimethylamino-phenyl)-1H-benzoimidazole-4-car...)

Ki: 5.80nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093365(2-Benzo[1,3]dioxol-5-yl-1H-benzoimidazole-4-carbox...)

Ki: 5.90nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093373(2-(3'-METHOXYPHENYL) BENZIMIDAZOLE-4-CARBOXAMIDE |...)

Ki: 6nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

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Details Article PubMed PDB

3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093374(2-(4-Hydroxy-phenyl)-1H-benzoimidazole-4-carboxyli...)

Ki: 6nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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PDB MMDB Reactome pathway
UniProtKB/SwissProt
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Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093375(2-(3-Hydroxy-phenyl)-1H-benzoimidazole-4-carboxyli...)

Ki: 6.30nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093360(2-(3-Hydroxymethyl-phenyl)-1H-benzoimidazole-4-car...)

Ki: 6.80nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM27684(2-(4-methoxyphenyl)-1H-1,3-benzodiazole-4-carboxam...)

Ki: 6.80nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093377(2-(4-Nitro-phenyl)-1H-benzoimidazole-4-carboxylic ...)

Ki: 8nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093382(2-(3-Trifluoromethyl-phenyl)-1H-benzoimidazole-4-c...)

Ki: 8nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093370(4-(4-Carbamoyl-1H-benzoimidazol-2-yl)-benzoic acid...)

Ki: 8.10nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093368(2-(3-Chloro-phenyl)-1H-benzoimidazole-4-carboxylic...)

Ki: 8.40nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093385(2-(2-Fluoro-phenyl)-1H-benzoimidazole-4-carboxylic...)

Ki: 9nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093380(2-(3-Allyloxy-4-methoxy-phenyl)-1H-benzoimidazole-...)

Ki: 9.40nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093369(2-(2-Chloro-phenyl)-1H-benzoimidazole-4-carboxylic...)

Ki: 9.40nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093378(2-(2-Hydroxymethyl-phenyl)-1H-benzoimidazole-4-car...)

Ki: 10.6nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093366(2-(4-Amino-phenyl)-1H-benzoimidazole-4-carboxylic ...)

Ki: 11nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093386(2-(4-Hydroxy-3-methoxy-phenyl)-1H-benzoimidazole-4...)

Ki: 13nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM27091(2-phenyl-1H-1,3-benzodiazole-4-carboxamide | CHEMB...)

Ki: 15nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093387(2-(4-Methoxy-phenyl)-1-methyl-1H-benzoimidazole-4-...)

Ki: 32nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093381(2-(4-Triisopropylsilanyloxymethyl-phenyl)-1H-benzo...)

Ki: 85nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM27088(1H-1,3-benzodiazole-4-carboxamide | 1H-benzimidazo...)

Ki: 95nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093363(2-Methyl-1H-benzoimidazole-4-carboxylic acid amide...)

Ki: 99nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)

Ki: 120nMAssay Description:Binding affinity for DNA dependent protein kinase isolated from HeLa cells; Range is 20-120More data for this Ligand-Target Pair

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Details Article PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)

Ki: 120nMAssay Description:Inhibition of human recombinant p110 alpha Phosphatidylinositol 3-kinaseMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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KEGG PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093371(2-(2-Methoxy-phenyl)-1H-benzoimidazole-4-carboxyli...)

Ki: 126nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093364(2-(3,4,5-Trimethoxy-phenyl)-1H-benzoimidazole-4-ca...)

Ki: 136nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093376(2-(2-Trifluoromethyl-phenyl)-1H-benzoimidazole-4-c...)

Ki: 190nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093388(4-(4-Carbamoyl-1H-benzoimidazol-2-yl)-benzoic acid...)

Ki: 290nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093358(2-Trifluoromethyl-1H-benzoimidazole-4-carboxylic a...)

Ki: 350nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

Alpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL

BDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)

Ki: 400nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3965 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093357(4-Carbamoyl-2-(4-methoxy-phenyl)-benzoimidazole-1-...)

Ki: 530nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

CHEMBL PC cid PC sid Patents

Alpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL

BDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)

Ki: 1.00E+3nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3130 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM27506(3-AB | 3-aminobenzamide | CHEMBL81977)

Ki: 3.10E+3nMAssay Description:In vitro inhibition against PARP L713F proteinMore data for this Ligand-Target Pair

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Alpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL

BDBM50168995((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)

Ki: 5.00E+3nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3990 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)

Ki: 6.00E+3nMAssay Description:Competitive inhibition of DNA-PK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)

Ki: 6.00E+3nMAssay Description:Binding affinity for Phosphatidylinositol-3-kinase isolated from HeLa cells; Range is 20-120More data for this Ligand-Target Pair

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Alpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL

BDBM50168995((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)

Ki: 1.40E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 2199 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair

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CHEMBL KEGG MMDB PC cid PC sid PDB Patents Similars

Alpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL

BDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)

Ki: 4.30E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3994 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair

Alpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL

BDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)

Ki: 4.60E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3991 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair

Alpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL

BDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)

Ki: 7.00E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 2948 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair

Alpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL

BDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)

Ki: 9.00E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 2199 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair

Alpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL

BDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)

Ki: 9.60E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3990 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL

BDBM50093367(2-(4-Hydroxy-phenyl)-1H-benzoimidazole-4-carboxyli...)

Ki: 1.00E+5nMAssay Description:In vitro inhibition against human full length PARP proteinMore data for this Ligand-Target Pair

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Alpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL

BDBM50482721(Kifunensine)

Ki: 1.40E+5nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3990 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair

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